Transition-Metal Catalysis: Sustainable Synthetic Chemistry
Course content
The goal of organic synthesis is to efficiently create valuable and interesting molecules sustainably. Towards this goal, modern research efforts seek to discover and invent powerful chemical reactions that make new bonds that are difficult or impossible to form using traditional methods.
This course will cover how metals can be used to perform such reactions. An emphasis will be made on the use of homogeneous complexes of late transition metals as catalysts. Basic concepts of organometallic reactivity will be introduced followed by a description of modern topics including but not limited to palladium-catalysed cross-coupling, asymmetric hydrogenation, and olefin metathesis.
Knowledge:
Synthesis and reactivity of metal complexes towards organic
moieties and ancillary ligands. Particular focus on
late-transition-metal catalysts and commonly encountered
transition-metal catalysed reactions, such as palladium-catalysed
cross-coupling, asymmetric hydrogenation, and olefin
metathesis.
Skills:
The student should be able to describe common catalytic cycles in
transition-metal catalysis that are encountered in synthetic
organic chemistry.
They should also be able to describe how ancillary ligands influence the metal catalyst in individual steps of these catalytic cycles.
Moreover, they should be able to describe off-cycle complexes or competing pathways that they may encounter when utilizing these reactions in organic synthesis.
Competences:
The student should be able to suggest a plausible catalytic cycle
for a range of transition-metal catalysed reactions, and identify
promising ligand candidates to promote a desired
reaction.
The teaching is divided into lectures by the teacher, and exercises (solved in class and solved by the students at home – discussed on the class). Special topics and own experiences will be included when appropriate in the context
- Organotransition Metal Chemistry: From Bonding to Catalysis. John Hartwig, University Science Books, 2010.
- The Organometallic Chemistry of the Transition Metals. Robert Crabtree, John Wiley & Sons, 2005.
Additional course material will be indicated on Absalon
Basic competencies in physical chemistry, quantum chemistry, inorganic chemistry are necessary as well as intermediate competencies in organic chemistry and organic synthesis (equivalent to NKEB21000U Grundlæggende organisk kemi (KemiOrg))
Academic qualifications equivalent to a BSc degree is recommended.
- ECTS
- 7,5 ECTS
- Type of assessment
-
Oral examination, 20 minutes (no preparation time)
- Examination prerequisites
-
Approval of 80% of homework assignments
- Aid
- No aids allowed
- Marking scale
- passed/not passed
- Censorship form
- No external censorship
- Re-exam
-
Same as the ordinary exam.
Non-approved home assignments must be handed in no later than 3 weeks before the re-exam.
Students must be informed no later than 2 weeks before the re-exam whether their assignments have been approved.
Criteria for exam assessment
See Learning Outcome
Single subject courses (day)
- Category
- Hours
- Lectures
- 30
- Preparation
- 100
- Theory exercises
- 45
- Project work
- 30
- Exam
- 1
- English
- 206
Kursusinformation
- Language
- English
- Course number
- NKEK26000U
- ECTS
- 7,5 ECTS
- Programme level
- Full Degree Master
- Duration
-
1 block
- Placement
- Block 3
- Schedulegroup
-
C
- Capacity
- No limitation – unless you register in the late-registration period (BSc and MSc) or as a credit or single subject student.
- Studyboard
- Study Board of Physics, Chemistry and Nanoscience
Contracting department
- Department of Chemistry
Contracting faculty
- Faculty of Science
Course Coordinator
- Craig Day (3-67776844676c6971326f7932686f)
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Kursusinformation for indskrevne studerende