Reactions and Synthesis in Medicinal Chemistry (KemiMed)

The topics are: C-alkylation; Formation and reactions of enolates; Stereospecific aldol-additions; Chiral auxilaries; Functional groups and molecular carbon framework; Movement of electrons in chemical reactions; Functional group transformations, including reductions and oxidations; Mitsunobu and related reactions; Alfa nucleophiles;  Understanding migration, rearrangement and fragmentation reactions; Radical reactions; Reactions involving carbenes and nitrenes; Reactions of boranes and stananes; Electrophiles from electronegative atoms; The influence of the electronegativity of atoms on chemical bonds and their stability; Pericyclic reactions; Click-chemistry;Transition-metal catalyzed reactions including a variety of cross-coupling reactions; Electrophilic and nucleophilic aromatic substitution  reactions; Charge dissipation and resonance; Framework reductions and oxidation reactions; Understanding of chemistry in 3D, assisted by MM2 of the Chem3D software available at KU for students; Expecting the unexpected; Case stories from the medicinal industry: Using advanced organic chemistry in synthesis of natural and medicinal products.