Course in Modelling of Physiological Systems
Course content
The course aims to equip students with the skills to understand and utilize biosimulation tools, as well as to apply mathematical modeling in the biomedical sciences. It emphasizes the dynamic aspects of regulatory mechanisms across various levels of biological organization, including cellular and systems physiology.
BSc programme in Medicine and Technology (Biomedical Engineering) (valgfrit kursus)
Open to other students with adequate prerequisites
At the end of the course the student is expected to be able:
Knowledge
-
To explain different approaches to modeling;
-
To understand mathematical/physics concepts (dynamical systems, stability analysis, oscillations, synchronization);
-
To understand simple computational algorithms used for modeling;
-
To explain main models and dynamics of excitable cells;
-
To explain mechanisms and mathematical description of calcium dynamics;
-
To understand mechanisms of insulin-glucose regulation and mathematical description of involved feedback loops;
-
To understand regulatory mechanisms of circadian rhythms and their simple mathematical models;
-
To understand mechanisms and mathematical description of vascular responses and kidney autoregulation.
Skills
-
To discuss modeling approaches depending on the purpose of study;
-
To apply mathematical/physical concept to a specific biomedical problem;
-
To formulate model of excitable cells and discuss their possible simplifications and dynamics;
-
To formulate a simple model for calcium oscillations and discuss possible dynamics;
-
To formulate a model of insulin-glucose regulation and discuss biosimulations relevant to diabetes;
-
To discuss applications of chronobiology and formulate a simple model of circadian rhythms;
-
To formulate a model for kidney autoregulation and discuss biosimulations relavant to hypertension;
-
Reproduce, modify and simulate models from scientific literature;
- Improve scientific and academic vocabulary of English language.
Competence
-
To formulate mechanism-based models and find appropriate methods to investigate them;
-
To interpret dynamical features of biomedical systems from biological and mathematical viewpoints;
-
To integrate fundamental knowledge from physics, mathematics, and biology to provide better understanding of regulatory mechanisms.
E-learning, lectures, and computer exercises
On-line video and lecture notes
Please, note that this is 5 ECTS course (2.5 ECTS is for the course certificate + 2.5 ECTS for the examination).
Campusnet DTU
Open for credit transfer students and other external students.
Credit transfer students:
https://healthsciences.ku.dk/education/for-students/credit-transfer-students/
Other external students:
http://healthsciences.ku.dk/education/exchange_guest_students/guest-students/
- ECTS
- 2,5 ECTS
- Type of assessment
-
Requirement to attend classes
- Type of assessment details
- Participation in exercises and approval of reports
- Aid
- All aids allowed except Generative AI
- Marking scale
- passed/not passed
- Censorship form
- No external censorship
An internal examiner
Criteria for exam assessment
To obtain the course certificate the student must be able:
Knowledge
-
To explain different approaches to modeling;
-
To understand mathematical/physics concepts (dynamical systems, stability analysis, oscillations, synchronization);
-
To understand simple computational algorithms used for modeling;
-
To explain main models and dynamics of excitable cells;
-
To explain mechanisms and mathematical description of calcium dynamics;
-
To understand mechanisms of insulin-glucose regulation and mathematical description of involved feedback loops;
-
To understand regulatory mechanisms of circadian rhythms and their simple mathematical models;
-
To understand mechanisms and mathematical description of vascular responses and kidney autoregulation.
Skills
-
To discuss modeling approaches depending on the purpose of study;
-
To apply mathematical/physical concept to a specific biomedical problem;
-
To formulate model of excitable cells and discuss their possible simplifications and dynamics;
-
To formulate a simple model for calcium oscillations and discuss possible dynamics;
-
To formulate a model of insulin-glucose regulation and discuss biosimulations relevant to diabetes;
-
To discuss applications of chronobiology and formulate a simple model of circadian rhythms;
-
To formulate a model for kidney autoregulation and discuss biosimulations relavant to hypertension;
-
Reproduce, modify and simulate models from scientific literature;
- Improve scientific and academic vocabulary of English language.
Competence
-
To formulate mechanism-based models and find appropriate methods to investigate them;
-
To interpret dynamical features of biomedical systems from biological and mathematical viewpoints;
-
To integrate fundamental knowledge from physics, mathematics, and biology to provide better understanding of regulatory mechanisms.
- ECTS
- 2,5 ECTS
- Type of assessment
-
Oral examination, 25 minutter
- Type of assessment details
- Oral exam, without preparation
- Examination prerequisites
-
Course certificate in Modelling of Physiological Systems
- Aid
- No aids allowed
- Marking scale
- 7-point grading scale
- Censorship form
- No external censorship
Several internal examiners
- Exam period
-
Please visit: https://sund.ku.dk/uddannelse/for-studerende/eksamensplaner/medicin-og-teknologi/
- Re-exam
-
Please visit: https://sund.ku.dk/uddannelse/for-studerende/eksamensplaner/medicin-og-teknologi/
Criteria for exam assessment
To obtain the grade 12, the student must be able to
Knowledge
-
To explain different approaches to modeling;
-
To understand mathematical/physics concepts (dynamical systems, stability analysis, oscillations, synchronization);
-
To understand simple computational algorithms used for modeling;
-
To explain main models and dynamics of excitable cells;
-
To explain mechanisms and mathematical description of calcium dynamics;
-
To understand mechanisms of insulin-glucose regulation and mathematical description of involved feedback loops;
-
To understand regulatory mechanisms of circadian rhythms and their simple mathematical models;
-
To understand mechanisms and mathematical description of vascular responses and kidney autoregulation.
Skills
-
To discuss modeling approaches depending on the purpose of study;
-
To apply mathematical/physical concept to a specific biomedical problem;
-
To formulate model of excitable cells and discuss their possible simplifications and dynamics;
-
To formulate a simple model for calcium oscillations and discuss possible dynamics;
-
To formulate a model of insulin-glucose regulation and discuss biosimulations relevant to diabetes;
-
To discuss applications of chronobiology and formulate a simple model of circadian rhythms;
-
To formulate a model for kidney autoregulation and discuss biosimulations relavant to hypertension;
-
Reproduce, modify and simulate models from scientific literature;
- Improve scientific and academic vocabulary of English language.
Competence
-
To formulate mechanism-based models and find appropriate methods to investigate them;
-
To interpret dynamical features of biomedical systems from biological and mathematical viewpoints;
-
To integrate fundamental knowledge from physics, mathematics, and biology to provide better understanding of regulatory mechanisms.
Single subject courses (day)
- Category
- Hours
- Lectures
- 24
- Preparation
- 65,2
- Practical exercises
- 24
- E-Learning
- 24
- Exam
- 0,3
- English
- 137,5
Kursusinformation
- Language
- English
- Course number
- SMTB20003U
- ECTS
- See exam description
- Programme level
- Bachelor
- Duration
-
1 semester
- Placement
- Autumn
- Schedulegroup
-
Mandag i tidsrummet 13-17/Mondays between 13-17
- Capacity
- 60 students
- Studyboard
- Study board from DTU
Contracting department
- Department of Biomedical Sciences
Contracting faculty
- Faculty of Health and Medical Sciences
Course Coordinator
- Olga Sosnovtseva (4-74716c6645787a736933707a336970)
Spørgsmål til undervisning eller holdsætning på dine KU-kurser, kontakt:
Undervisning@sund.ku.dk
Spørgsmål til og examiner på dine KU-kurser, kontakt:
eksamen@sund.ku.dk
Spørgsmål til studieplanlægning på SUND, kontakt:
vejledning@sund.ku.dk
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