Translational Tools II – New Methods
Course content
The main themes covered in the course include:
- Stem cells and their applications in disease modeling and regenerative medicine
- CRISPR and screening technologies
- Target selection and validation
- Using deep learning tools to interrogate in vitro cell type identity
BRIDGE – Translational Excellence Programme
Upon completing the course, participants should be able to:
Knowledge
Explain the rationale for the utilization of several advanced research methodologies to discover new therapeutic targets with a focus on these general areas:
- Stem cell models
- Gene editing
- High-content screening
- Technologies for identifying/validating therapeutic targets
- Bioinformatic identification of cell types
Skills
- Design constructs for CRISPR-based gene targeting
- Introduce constructs to pluripotent stem cells
- Basic principles and applications of flow cytometry and light microscopy
- Determine significant hits from a screen
Competences
- Understand how stem cell-based models can be used to treat human diseases
- Identify and evaluate advantages and limitations of the using high-content screening platforms
- Distinguish the central aspects of translational tools and be able to discuss and communicate these to other scientists, clinicians, and the public.
The course will include lectures from reNEW scientists with a
visiting lecturer, covering topics around stem cell models,
CRISPR-based genome engineering, high-content screening methods, as
well as the applications of technologies for identifying
translational targets. The invited speaker will also give an open
research seminar that will be included as a component of the
course.
In addition, the course will include group work, demonstrations,
and practical exercises supervised by specialists in the field.
The course will end with small group discussions and an evaluation
where participants must reflect on course learning outcomes and
give feedback for course development.
Course literature will be published on Absalon.
Participants must meet the admission criteria of the BRIDGE – Translational Excellence Programme.
The BRIDGE – Translational Excellence Programme offers a small number of selected PhD graduates a two-year postdoctoral fellowship in translational medicine. This course is only available to the fellows enrolled in the programme. Fellows are automatically enrolled upon admission.
For further information about the programme, please visit the website: www.bridge.ku.dk
- ECTS
- 0 ECTS
- Type of assessment
-
Continuous assessmentRequirement to attend classes
- Type of assessment details
- Attendance and active participation are required.
- Examination prerequisites
-
Participants are automatically registered for the examination upon admission to the BRIDGE – Translational Excellence Programme.
- Aid
- All aids allowed
- Marking scale
- passed/not passed
- Censorship form
- No external censorship
Criteria for exam assessment
Active contribution and course participation according to the BRIDGE Guidelines and Practicalities.
Part time Master and Diploma courses
- Category
- Hours
- Lectures
- 10
- Preparation
- 5
- Theory exercises
- 5
- Exercises
- 20
- English
- 40
Kursusinformation
- Language
- English
- Course number
- SBRI19011U
- ECTS
- 0 ECTS
- Programme level
- Part Time Master
Ph.D.
- Placement
- Autumn
- Schedulegroup
-
See course dates and programme in Absalon.
*This course description applies to the course running in 2025 as part of the 2024-2026 BRIDGE Academic Curriculum. - Capacity
- 15 participants
- Studyboard
- Study Board for the Professionel Master´s Degree Programmes at The Faculty og Health and Medical Science
Contracting department
- Center for Stem Cell Medicine (reNEW)
Contracting faculty
- Faculty of Health and Medical Sciences
Course Coordinators
- Joshua Mark Brickman (15-757a7e73806c396d7d746e76786c794b7e80796f397680396f76)
- Molly Pleasants Lowndes (13-767875758237757880776d6e7c497c7e776d37747e376d74)
Er du BA- eller KA-studerende?
Kursusinformation for indskrevne studerende