Pharmacology: From Physiology to Therapy

Course content

The course covers the following themes. Themes in BOLD will have associated projects and tutorials from which a student outcome (written report, oral presentation or class exercise) is expected.

  • Cardiovascular: Structure, function and pathophysiology of the cardio-vascular system and the drug classes applied to the system.
  • Respiratory: Structure and function of the respiratory system, including the transport of gasses in the blood, lung diseases and drug classes for treatment of respiratory diseases.
  • Kidney: The function of the kidney with emphasis on clearance and functions of the nephrons, including excretion of drugs. The role of the kidney in acid/base regulation, salt- and water balance and actions of medicines which disturb homeostasis.
  • Endocrinology: The physiology of hormone producing organs, including glucose regulating hormones, calcium regulating hormones, growth hormones, thyroid hormones, anabolic steroids, sex hormones and glucocorticoids. Energy transformation and temperature regulation including drugs for treatment of obesity and antipyretics and diseases related to the above hormones.
  • Central Nervous System: Structure and function of the central nervous system, including actions of drugs indicated in the treatment of neurodegenerative diseases, psychosis, depression, epilepsy, pain, sleep disorders, anxiety and drug addiction/abuse.
  • Pain: Central and peripheral physiology of pain and treatment/mechanisms of action of pain with analgesics.
  • Structure and function of the gastrointestinal tract (GI), the liver and the pancreas with emphasis on drug actions on the function and diseases of the GI tract including the liver and the pancreas.
  • The physiology of the immune system and its diseases; allergy and autoimmunity (rheumatoid arthritis). Immunomodulators including: biologicals (mabs), antihistamines, and vaccines. Infections (bacterial, parasite, microbes and viral) and their treatments.
  • Cancer mechanisms and treatment with cytotoxic drugs.
  • Novel Treatments: gene therapy and adenovirus vectors
Education

MSc Programme in Pharmaceutical Sciences (English programme): Study track I ('Drug Discovery' study track) & III ('Medicines and Society' study track) - compulsory

MSc Programme in Pharmaceutical Sciences (English programme): Study track II - restricted elective

 

Learning outcome

This course has two overall goals and two different methods of assessment of success of these goals (see later assessment section):

  • To ensure students gain fundamental knowledge relevant to pharmaceutical science:
    Students must attain a basic familiarity with human physiology and understanding of the mechanisms of action of pharmacological management of disorders. Accordingly, this course is designed to instil in students an anatomical and physiological knowledge about the structure and function of organs, including the effects of commonly-appearing diseases upon organ systems. On the basis of this knowledge, students should understand not only the effects of pharmacotherapies, but also the mode of action and the principles behind safe and rational use of drugs. This goal will be assessed with a written exam.
     
  • To ensure students gain skills to perform a task within pharmaceutical sciences:
    Students must learn how to apply knowledge they have acquired in pensum material to real world problems. This goal will be assessed by active participation in tutorials and projects necessitating completion of a specific product based task. Tutorials and projects are designed to draw from pensum material so that students gain experience putting learned material into practical use. Attendance at, and participation in, tutorials and projects is expected to solidify and assist in retention of pensum material. Within six main themes, students will be expected to create a product (oral presentation or written report). Within two of these six themes, students will be expected in a project to read a basic research paper directly relevant to pensum material. They will present this paper exhibiting the ability to extract relevant information. By conducting tutorial and project tasks, students will be encouraged to exhibit intellectual independence and choice.

 

At the end of the course, students are expected to be able to:

Knowledge

  • explain in depth the basic function of major organs. The latter includes the modulation and feedback systems involved in maintaining homeostasis.
  • explain the consequences of pathophysiological disturbances in single organs and organ systems, including drugs to treat these disturbances.
  • reflect on the target for the action, the indication and contraindication for treatment with commonly used drugs.
  • explain virus biology and potential strategies for development of anti-viral pharmacological agents.

 

Skills

  • perform basic calculations based on kidney, cardiac and respiratory lectures and tutorials.
  • communicate the properties of classes of commonly used drugs used for treatment of major diseases.
  • read a primary research report related to the lecture material with the ability to extract relevant information and biomedical significance.

 

Competences

  • propose a relevant pharmacological intervention for a patient with a known disease on the basis of a relevant patient description.

•69 lectures (45-minutes)
•39 class tutorials/projects (45-minutes)
•8 class-room exercises/laboratory work (45-minutes)

  • The most recent edition available in the book store of Rang, H.P., Ritter, J.M., Flower, R.J. & Henderson, G.: Rand and Dale's Pharmacology, Elsevier, Churchill Livingstone.
  • The most recent edition available in the book store of Silverthorn D.V: Human Physiology
  • Notes distributed by teachers in topics including kidney, cardiovacular system and respiratory system. 

 

Recommended, not required:

Chiasera, Hardy and Smith: Quick guide to Clinical Chemistry, AACC Press 2006

If you are applying for the course as a credit transfer student, you must have passed Organisk kemi I -fysisk kemiske egenskaber, Organisk kemi II syntese af lægemiddel-stoffer, Organfarmakologi, Biopharmaceuticals -bioorganisk kemi and Principles of Pharmacology or have acquired similar competencies in another course. Documentation for corresponding competencies in the form of a course description and an exam result must be attached to your application

Oral
Collective
Continuous feedback during the course of the semester
ECTS
15 ECTS
Type of assessment
On-site written exam, 3 hours under invigilation
Type of assessment details
The written examination consists of a set of problems, which may include calculations, that draw from course content and must be answered without assistance of written materials. The individual weight of the problems and the questions are designated in the examination set.

The general impression is part of the assessment and may give rise to an adjustment of up to 10% of the score. Such an adjustment is based on the student’s demonstration of an overall knowledge of basic pharmacological principles and topics, and the absence of severe voids in the attempt.

In order to access the development of skills to perform tasks with the knowledge presented, the student will be asked to exhibit participation in tutorials or projects within the 6 themes selected in the "Content" section. Participation will be defined by a student outcome (product) which will vary from oral presentation to written report.
Participation in these tasks is mandatory for eligibility to take the written examination.

Active participation in 6 student assignments is a prerequisite for attending the exam.
Aid
Without aids

Find more information about written on-site exams in the exam rooms, incl. information about standard programs on the exam PCs at KUnet

Written on-site exam - KUnet

Marking scale
7-point grading scale
Censorship form
External censorship
Re-exam

10 or fewer students registered for reexam:

Type of assessment: Oral examination

Assessment details: 20 minutes examination

Preparation: 20 minutes

Aids: None (Blank paper and pens, and calculators of necessary will be provided at the exam during the preparation period)

Criteria for exam assessment

To achieve the grade 12 the student must be able to:

Knowledge

  • demonstrate with aplomb a comprehensive view of pharmacological principles, and convincingly combine the learned elements.
  • demonstrate with few deficiencies, a mastery of relevant terms, principles and methods used in the process of drug development from discovery to production.
  • explain in depth the basic function of major organs. The latter includes the modulation and feedback systems involved in maintaining homeostasis.
  • explain the consequences of pathophysiological disturbances in single organs and organ systems, including drugs to treat these disturbances.
  • reflect on the target for the action, the indication and contraindication for treatment with commonly used drugs.
  • explain virus biology and potential strategies for development of anti-viral pharmacological agents.

 

  • Skills

  • perform basic calculations based on kidney and respiratory lectures and tutorials.
  • communicate the properties of classes of commonly used drugs used for treatment of major diseases.
  • read a primary research report related to the lecture material with the ability to extract relevant information and biomedical significance.

 

Competences

  • propose a relevant pharmacological intervention for a patient with a known disease on the basis of a relevant patient description.

Single subject courses (day)

  • Category
  • Hours
  • Lectures
  • 69
  • Preparation
  • 256
  • Practical exercises
  • 8
  • Project work
  • 39
  • Exam
  • 40
  • English
  • 412

Kursusinformation

Language
English
Course number
SLVKB0362U
ECTS
15 ECTS
Programme level
Full Degree Master
Duration

1 block

Placement
Block 3
Schedulegroup
A And B
Capacity
40 students.
Studyboard
Study Board of Pharmaceutical Sciences
Contracting department
  • Department of Drug Design and Pharmacology
Contracting faculty
  • Faculty of Health and Medical Sciences
Course Coordinator
  • Kristi Anne Kohlmeier   (4-7c727c425184867f753f7c863f757c)
Saved on the 28-06-2024

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