Principles of Pharmacology
Course content
The course deals with the following topics:
- Neurotransmitter systems and neuropharmacology
- Fundamental nerve/muscle/cell physiology with special focus on membrane physiology and synaptic mechanisms
-
Receptor pharmacology including receptor classifications, agonists, antagonists, development of tolerance, and analysis of receptor-ligand interactions
-
Pharmacodynamics: Dose-response relationships, dose/time relationships, use of biological systems to estimate activities of drugs, statistical analysis of biological data
-
Pharmacokinetics: General kinetics, absorption, distribution, elimination, metabolism, excretion and drug interactions
-
Drug development methods: Animal models, preclinical development, and concepts of toxicology
MSc Programme in Pharmaceutical Sciences (English programme) -
compulsory
At the end of the course, students are expected to be able to:
Knowledge
- Students will obtain a fundamental understanding and knowledge of the basic concepts of pharmacology and the related human physiology.
Skills
- calculate pharmacokinetic parameters of a drug from plasma concentrations time-course
- understand the different mechanisms of action of antagonists
- interpret antagonist pharmacological data to determine the mechanism of action
- propose experiments to distinguish antagonist mechanism of action
- have a basic understanding of neurotransmission and neurotransmitter systems in the CNS
- have an understanding of drug toxicity and adverse effects
- have an understanding of clinical trials and drug monitoring
Competencies
- understand concepts used in physiology and basic pharmacology.
- calculate, estimate and discuss physiological and pharmacological parameters obtained from experimental and clinical data (pharmacodynamic and pharmacokinetic data).
- discuss and explain pharmacology-related procedures and methods used in preclinical drug development.
- effectively communicate pharmacological and drug information to others within the fields of pharmaceutical sciences and health sciences
• 31 lectures
• 20 hr of tutorial lessons
• 1 project presentation (group work)
- Silverthorn: Human Physiology, 7th edition, Pearson International, 2016.
- Rang, H.P., Dale, M.M., Ritter, J.M. & Flower, R. J.: Pharmacology, 8th edition, Churchill Livingstone, 2015.
- Rowland, M. & Tozer, T.N.: Clinical Pharmacokinetics and Pharmacodynamics. Concepts and Applications. 4th edition, Lippincott, Williams & Wilkins, 2011.
- Meldgaard Lund, T. and Sheykhzade M., FARMA, KU: Pharmacokinetic and -dynamic Equations and Preconditions (on the homepage).
- Sheykhzade and Pickering: Pharmacodynamic theory notes, 9th ed, 2013 (on the homepage).
Course teaching is based on the assumption that students have passed exams in chemistry subjects corresponding to at least 15 ECTS credits, of which 10 ECTS credits should be in organic chemistry and biology, and 15 ECTS credits in biochemistry and/or molecular biology and/or microbiology.
If you are applying for the course as a credit transfer student, you must have passed SFAB20029U Organisk kemi II - syntese af lægemiddel-stoffer, SFAB20027U Farmaceutisk biologi and SFAB20015U Biopharmaceuticals -bioorganisk kemi or have acquired similar competencies in another course. Documentation for corresponding competencies in the form of a course description and an exam result must be attached to your application.
Except for students enrolled at the MPS this course is NOT available to those who have previously passed an introductory pharmacology lecture course, such as: almen farmakologi (SFABB0251U) or grundlæggende farmakologi (SFABB1011U).
The course contains a literature project module, where evaluation and performance feedback will be given verbally by the project teacher as well as peer feedback from fellow students.
Open for credit transfer students and other external students. Apply here:
Credit transfer students:
Credit transfer student at SUND – University of Copenhagen
(ku.dk)
Other external students:
http://healthsciences.ku.dk/education/student-mobility/guest-students/
Credit transfer and other external students are welcomed on the course if there are seats available and they have the academic qualifications.
- ECTS
- 7,5 ECTS
- Type of assessment
-
Written examination, 3 hours under invigilation
- Type of assessment details
- Exam assessment is based on a written, closed-book exam with 4
different topics and each topic with 4 subparts. The individual
weighting of each question will be clearly stated on the exam
paper.
Overall impression forms part of the exam assessment and may cause the score to be adjusted by up to 10%. The adjustment is based on the demonstration of an overall understanding of basic pharmacological principles and topics and the absence of major weaknesses. - Aid
- Without aids
Find more information about written on-site exams in the exam rooms, incl. information about standard programs on the exam PCs at KUnet
- Marking scale
- 7-point grading scale
- Censorship form
- No external censorship
Criteria for exam assessment
To achieve the grade 12 the student must be able to:
Knowledge
- understand the relevant terms, principles and methods used in physiology and pharmacology.
- refer fundamental understanding and knowledge of the basic concepts of pharmacology and the related human physiology.
- understand the basics of neurotransmission and neurotransmitter systems in the CNS
- understand drug toxicity and adverse effects
- understand clinical trials and drug monitoring
- understand concepts used in physiology and basic pharmacology.
Skills
- calculate pharmacokinetic parameters of a drug from plasma concentrations time-course
- understand the different mechanisms of action of antagonists
- interpret antagonist pharmacological data to determine the mechanism of action
- propose experiments to distinguish antagonist mechanism of action
Competencies
- calculate, estimate and discuss physiological and pharmacological parameters obtained from experimental and clinical data (pharmacodynamic and pharmacokinetic data).
- discuss and explain pharmacology-related procedures and methods used in preclinical drug development.
- effectively communicate pharmacological and drug information to others within the fields of pharmaceutical sciences and health sciences
Single subject courses (day)
- Category
- Hours
- Lectures
- 31
- Class Instruction
- 40
- Preparation
- 65
- Project work
- 20
- Exam Preparation
- 50
- English
- 206
Kursusinformation
- Language
- English
- Course number
- SLVKB0352U
- ECTS
- 7,5 ECTS
- Programme level
- Full Degree Master
- Duration
-
1 block
- Placement
- Block 1
- Schedulegroup
-
A
- Capacity
- 70 students.
- Studyboard
- Study Board of Pharmaceutical Sciences
Contracting department
- Department of Drug Design and Pharmacology
Contracting faculty
- Faculty of Health and Medical Sciences
Course Coordinator
- Anders Skov Kristensen (3-63756d4275777066306d7730666d)
Teacher
Annouced at course start.
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Kursusinformation for indskrevne studerende