Synthesis and reactivity of simple heteroaromatic compounds: pyridines, quinolines, diazines, pyrylium salts, pyrones, furans, thiophenes, indoles and different five-membered rings with two heteroatoms. Nomenclature in heterocyclic chemistry. Some applications of heterocyclic compounds.
MSc Programme in Medicinal Chemistry
The student should be able to suggest syntheses of simple heterocyclic compounds and explain the reactivity of heteroaromatic compounds.
The student should be able to identify differences in reactivities of heterocyclic compounds and be able to demonstrate how heterocyclic compounds can be prepared from simple starting materials. Moreover, the student should be able to name both mono- and polycyclic heterocyclic compounds.
Synthesis and reactivity of heterocyclic compounds. Particular focus on pyridines, quinolines, diazines, pyrylium salts, pyrones, furans, thiophenes, pyrrols, indoles, benzothiophenes, and benzofurans.
Lectures + Class room exercises
J. A. Joule, K. Mills, ”Heterocyclic Chemistry”, 5th Ed.,
M. B. Nielsen, Notes: Naming Heterocyclic Compounds
The student should be familiar with the general chemistry of the
carbonyl group, including nucleophilic addition, conjugate
addition, nucleophilic substitution at the carbonyl group, imine
formation, enolate formation, and specific enol equivalents. In
regard to carbonyl chemistry, the student should be familiar with
the aldol and Claisen ester condensations. In addition, knowledge
on the Diels-Alder cycloaddition is expected. Terms such as regio-,
chemo-, and stereoselectivity are prerequisites as well as
knowledge on common protecting groups for carbonyls, amines, and
Academic qualifications equivalent to a BSc degree is recommended.
- 7,5 ECTS
- Type of assessment
Written examination, 4h under invigilation
- Type of assessment details
- Written exam with exercises testing whether the student has gained the knowledge, skills and competences as described above. Specifically, the student should be able to evaluate reactivity of various heterocycles and be able to design synthetic protocols for their preparation.
- Without aids
- Marking scale
- 7-point grading scale
- Censorship form
- No external censorship
Several internal examiners
Criteria for exam assessment
The student should satisfy the learning outcomes.
Single subject courses (day)
- Theory exercises
- Course number
- 7,5 ECTS
- Programme level
- Full Degree Master
- Block 3
- No admission restriction
The number of seats may be reduced in the late registration period
- Study Board of Physics, Chemistry and Nanoscience
- Department of Chemistry
- Faculty of Science
- Mogens Brøndsted Nielsen (3-7d727e507378757d3e7b853e747b)
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