Reactions and Synthesis in Medicinal Chemistry (KemiMed)

The topics are: Formation and reactions of enolates; Stereospecific aldol-additions; Chiral auxilaries; Reduction of organic funtional groups; Pericyclic reactions including click-chemistry; Rearrangements; Fragmentations; Radical reactions including carbenes; Methods for the resolution of racemic mixtures: Classical resolution, enzymatic resolution and methods for determination of optical purity; Transition-metal catalyzed reactions including cross-coupling reactions; Stereospecific aldol-additions; Chiral auxilaries; Pericylic Aromatic substitution  reactions; Oxidation reactions including click-chemistry; Rearrangements; Fragmentations; Radical reactions including carbenes; Microorganisms and enzymes in synthesis; Methods for the resolution of racemic mixtures: Classical resolution, enzymatic resolution, spontaneous resolution and methods for determination of optical purity; Microfluidics in synthesis; Solid-phase supported reagents for synthesis; Case stories from the medicinal industry: What is an invention? Scalability problems.and reagents; Patents and how to use the patent literature.