Reactions and Synthesis in Medicinal Chemistry (KemiMed)
The topics are: Formation and reactions of enolates; Stereospecific aldol-additions; Chiral auxilaries; Reduction of organic funtional groups; Pericyclic reactions including click-chemistry; Rearrangements; Fragmentations; Radical reactions including carbenes; Methods for the resolution of racemic mixtures: Classical resolution, enzymatic resolution and methods for determination of optical purity; Transition-metal catalyzed reactions including cross-coupling reactions; Stereospecific aldol-additions; Chiral auxilaries; Pericylic Aromatic substitution reactions; Oxidation reactions including click-chemistry; Rearrangements; Fragmentations; Radical reactions including carbenes; Microorganisms and enzymes in synthesis; Methods for the resolution of racemic mixtures: Classical resolution, enzymatic resolution, spontaneous resolution and methods for determination of optical purity; Microfluidics in synthesis; Solid-phase supported reagents for synthesis; Case stories from the medicinal industry: What is an invention? Scalability problems.and reagents; Patents and how to use the patent literature.
MSc Programme in Chemistry
MSc Programme in Chemistry with a minor subject
MSc Programme in Medicinal Chemistry
Be able to analyze a complex synthetic problem and plan a feasible synthesis.
Be able to analyze scientific papers and patents dealing with synthetic problems and be able to spot inconsistent claims.
Apply the aquired knowledge on organic synthesis on a given target molecule. Be able to translate known methodologies to new problems.
Have an in depth knowledge of modern synthetic organic synthesis according to the content of the course.
Lectures, problem solving in class and written exam
Will be announced on Absalon
Basic competencies physical chemistry, quantum chemistry,
inorganic chemistry are necessary and intermediate competencies in
organic chemistry and organic synthesis are necessary
(equivalent to KemiOrg and (Vid)OrgSyn).
Academic qualifications equivalent to a BSc degree is recommended.
- 15 ECTS
- Type of assessment
Written examination, 4 timer under invigilation...
- Only certain aids allowed
The textbook is allowed
- Marking scale
- 7-point grading scale
- Censorship form
- No external censorship
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Criteria for exam assessment
See Learning Outcome
Single subject courses (day)
- Theory exercises
- Course number
- 15 ECTS
- Programme level
- Full Degree Master
- Block 1 And Block 2
- No admission restriction
- Study Board of Physics, Chemistry and Nanoscience
- Department of Chemistry
- Faculty of Science
- Morten Peter Meldal (6-766e756d6a75496c716e7637747e376d74)
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Courseinformation of students