Molecular Cell Biology
A series of Group Discussions (no lectures) in which prepared material is treated and discussed, and three weeks of laboratory exercises where a range of experimental techniques is carried out and concepts taught. In the theoretical part of the course as well as in the experimental part, the main emphasis is on the parts of molecular cell biology that deals with gene expression, signaling, and regulation of cell growth, with examples referring to the molecular mechanisms and signaling in growth and cancer. The textbook is only used as reference – we will not go through it. The final evaluation focuses on understanding experimental detail and interpretation of experimental data rather than on recitation of facts.
BSc Programme in Biochemistry
BSc Programme in Biology
The main goal of the course is for the student to develop an
understanding of how knowledge in molecular cell biology is
obtained through experimental approaches; an aim particularly
important and appropriate close to the point of the bachelor
project. This objective is reached through discussion of selected
aspects of molecular cell biology, many of which deal with the
changes taking place in cancer cells. Through discussion of
experiments and their results, by in-debt evaluation of primary
data from publications, as well as de-novo interpretation of
presented data, the student is expected to obtain the ability to
demonstrate specific knowledge, to read, understand and follow the
validity of conclusions from experimental data from primary
scientific literature, and use this knowledge when planning and
Students can identify, describe, and name specific research areas including different experimental and theoretical approaches; can identify a subset of instruments and devices used in molecular and cellular biological experiments.
Students can describe the use of a number of molecular biological techniques; in particular those done at the lab-course, but also methods that combine and exploit known pieces in new combinations.
Based on protocols for laboratory experiments, the student can carry out experiments and assess results.
Based on presented experimental results, the student can argue for the conclusions drawn, point out important controls, compare results from different conditions and evaluate them.
Based on original research literature, posed problems and experience with laboratory exercises, the student can explain the purpose of specific experiments, the materials used in experimental designs, the procedures involved and the format of results obtained. The student can use a subset of instruments and devices used in molecular and cellular biological experiments and explain results obtained, and will have first hand experience of generation of primary data.
Students can use obtained and already acquired knowledge within molecular biology to understand the use of, limitations of, and interpretation of, results from experiments and methods within molecular biology.
- can assess the importance of the activity of proteins in detail, in relation to molecular cell biology and how these activities can be affected by mutations, other proteins, as well as other activities, and the consequences of such influences
- can evaluate the detailed description of an experimental protocol, and can form conclusions from primary as well as derived data
- can evaluate which results from experiments are solid, important and significant
- can recognize controls in the experiments, and understand which parameters these control for
- can understand the experimental background for the conclusions drawn in original research papers dealing with molecular cell biology topics
- can understand the importance of and carry out quantitative calculations as used in the laboratory-course or illustrated in class.
Group discussions and laboratory course.
It is necessary that the student has solid knowledge of basic
biochemistry and molecular biology. Furthermore, experience with
reading original scientific literature is an advantage. Students
should have qualifications corresponding to one of the following
sets of courses:
A: Molecular Biology, Genetics and Biotechnology (Molekylærbiologi, genetik og bioteknologi) and Protein Science and Enzyme Technology (Proteinvidenskab og enzymteknologi) of the bachelor curriculum for biochemistry students.
B. Protein Chemistry and Enzymology I and II (Proteinkemi og enzymologi I og II), Molecular Biology (Molekylærbiologi) and Cell Biology (Medicinsk celle- og vævsbiologi) of the bachelor curriculum for molecular biomedicine students
C. General Biochemistry (Almen biokemi), General Molecular Biology (Almen Molekylærbiologi) and General Cell Biology (Almen Cellebiologi) of the bachelor curriculum for biology students.
All written material including the exam are in English.
- 15 ECTS
- Type of assessment
Written examination, 4 hours under invigilation---
The course has been selected for ITX exam
- All aids allowed
The University will make computers available to students taking on-site exams at ITX. Students are therefore not permitted to bring their own computers, tablets or mobile phones. If textbooks and/or notes are permitted, according to the course description, these must be in paper format or uploaded through Digital Exam.
- Marking scale
- 7-point grading scale
- Censorship form
- External censorship
Criteria for exam assessment
In order to obtain the grade 12 the student should convincingly and accurately demonstrate the knowledge, skills and competences described under Learning Outcome.
Single subject courses (day)
- Class Instruction
- Practical exercises
- Course number
- 15 ECTS
- Programme level
- Block 2
A, B and C
- Study Board for the Biological Area
- Department of Biology
- Faculty of Science
- Olaf Nielsen (6-74736e6c6a7345676e7433707a336970)
Peter Brodersen, Vibe Østergaard, Michael Lisby, Anders Løbner-Olesen, Olaf H. Nielsen.
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