Reactions and Synthesis in Medicinal Chemistry (KemiMed)
Course content
The topics are: Formation and reactions of enolates; Stereospecific aldol-additions; Chiral auxilaries; Reduction of organic funtional groups; Pericyclic reactions including click-chemistry; Rearrangements; Fragmentations; Radical reactions including carbenes; Methods for the resolution of racemic mixtures: Classical resolution, enzymatic resolution and methods for determination of optical purity; Transition-metal catalyzed reactions including cross-coupling reactions; Stereospecific aldol-additions; Chiral auxilaries; Pericylic Aromatic substitution reactions; Oxidation reactions including click-chemistry; Rearrangements; Fragmentations; Radical reactions including carbenes; Microorganisms and enzymes in synthesis; Methods for the resolution of racemic mixtures: Classical resolution, enzymatic resolution, spontaneous resolution and methods for determination of optical purity; Microfluidics in synthesis; Solid-phase supported reagents for synthesis; Case stories from the medicinal industry: What is an invention? Scalability problems.and reagents; Patents and how to use the patent literature.
MSc Programme in Chemistry
MSc Programme in Chemistry with a minor subject
MSc Programme in Medicinal Chemistry
Competencies
Be able to analyze a complex synthetic problem and plan a feasible
synthesis.
Be able to analyze scientific papers and patents dealing with
synthetic problems and be able to spot inconsistent claims.
Skills
Apply the aquired knowledge on organic synthesis on a given target
molecule. Be able to translate known methodologies to new problems.
Knowledge
Have an in depth knowledge of modern synthetic organic synthesis
according to the content of the course.
Lectures, problem solving in class and written take-home assignments
Will be announced on Absalon
Basic competencies physical chemistry, quantum chemistry,
inorganic chemistry are necessary and intermediate competencies in
organic chemistry and organic synthesis are necessary
(equivalent to KemiO and (Vid)OrgSyn).
Academic qualifications equivalent to a BSc degree is
recommended.
- ECTS
- 15 ECTS
- Type of assessment
-
Oral examination, 30 minThe exam is an oral examination based on one of the take-home assignments chosen randomly (by lot). There is no preparation time
- Aid
- Without aids
- Marking scale
- 7-point grading scale
- Censorship form
- No external censorship
flere interne bedømmere
Criteria for exam assessment
See Learning Outcome
Single subject courses (day)
- Category
- Hours
- Lectures
- 26
- Preparation
- 333
- Theory exercises
- 52
- Exam
- 1
- English
- 412
Kursusinformation
- Language
- English
- Course number
- NKEK13007U
- ECTS
- 15 ECTS
- Programme level
- Full Degree Master
- Duration
-
2 blocks
- Schedulegroup
-
A
- Capacity
- No admission restriction
- Studyboard
- Study Board of Physics, Chemistry and Nanoscience
Contracting department
- Department of Chemistry
Contracting faculty
- Faculty of Science
Course Coordinator
- Jørn Bolstad Christensen (3-6e666744676c6971326f7932686f)
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Courseinformation of students