Reactions and Synthesis in Medicinal Chemistry (KemiMed)

Course content

The topics are: Transition-metal catalyzed reactions including cross-coupling reactions; Stereospecific aldol-additions; Chiral auxilaries; Pericylic reactions including click-chemistry; Rearrangements; Fragmentations; Radical reactions including carbenes; Microorganisms and enzymes in synthesis; Methods for the resolution of racemic mixtures: Classical resolution, enzymatic resolution, spontaneous resolution and methods for determination of optical purity; Microfluidics in synthesis; Solid-phase supported reagents for synthesis; Case stories from the medicinal industry: What is an invention? Scalability problems.


MSc Programme in Chemistry
MSc Programme in Medicinal Chemistry

MSc Programme in Chemistry with a minor subject

Learning outcome


Be able to analyze a complex synthetic problem and plan a feasible synthesis.
Be able to analyze scientific papers and patents dealing with synthetic problems and be able to spot inconsistent claims.

Apply the aquired knowledge on organic synthesis on a given target molecule. Be able to translate known methodologies to new problems.

Have an in depth knowledge of modern synthetic organic synthesis according to the content of the course.


Lectures, problem solving in class and written take-home assignments

Will be announced on Absalon

Basic competencies physical chemistry, quantum chemistry, inorganic chemistry are necessary and intermediate competencies in organic chemistry and organic synthesis  are necessary (equivalent to KemiO and (Vid)OrgSyn).

Academic qualifications equivalent to a BSc degree is recommended.

Continuous feedback during the course of the semester
Feedback by final exam (In addition to the grade)
Type of assessment
Oral examination, 30 min
The exam is an oral examination based on one of the take-home assignments chosen randomly (by lot). There is no preparation time
Without aids
Marking scale
7-point grading scale
Censorship form
No external censorship
flere interne bedømmere
Criteria for exam assessment

See Learning Outcome


Single subject courses (day)

  • Category
  • Hours
  • Lectures
  • 26
  • Theory exercises
  • 52
  • Preparation
  • 333
  • Exam
  • 1
  • English
  • 412