Exam in Modelling of Physiological Systems


BSc programme in Medicine and Technology (Biomedical Engineering)

2,5 ECTS
Type of assessment
Oral examination, 25 minutes
Oral exam, without preparation
Without aids
Marking scale
7-point grading scale
Censorship form
No external censorship
Several internal examiners
Criteria for exam assessment

To obtain the grade 12, the student must be able to


  • Explain different approaches to modeling

  • Understand mathematical/physics concepts (dynamical systems, stability analysis, oscillations, synchronization)

  • Understand simple computational algorithms used for modeling

  • Explain main models and dynamics of excitable cells

  • Explain mechanisms and mathematical description of calcium dynamics

  • Understand mechanisms of insulin-glucose regulation and mathematical description of involved feedback loops

  • Understand mechanisms and mathematical description of vascular responses and kidney autoregulation

  • Understand regulatory mechanisms of circadian rhythms and their simple mathematical models


  • Discuss modeling approachesdepending on the purpose of study

  • Apply mathematical/physical concept to particular biomedical problem

  • Formulate model of excitable cells and discuss their possible simplifications and dynamics

  • Formulate a simple model for calcium oscillations and discuss possible dynamics

  • Formulate a model of insulin absorption and insulin-glucose regulation, perform analysis of the observed phenomena and discuss their relevance to diabetes

  • Formulate a model for kidney autoregulation, perform analysis of the observed phenomena and discuss their relevance to hypertension

  • Discuss applications of chronobiology and formulate a simple model of circadian rhythms

  • Reproduce, modify and simulate models from scientific literature

  • Improve scientific and academic vocabulary of English language



  • To formulate mechanism-based models and find appropriate methods to investigate them

  • To interpret dynamical features ofbiomedical systems from biological and mathematical points of view

  • To integrate fundamental knowledge from physics, mathematics and biology to provide better understanding of regulatory mechanisms

Single subject courses (day)