Pharmaceutical Analytical Chemistry

Course content

Study groups and exercises constitute an integrated course package. The course provides a background for selecting and developing analytical methods and assessing the reliability of analytical data. A variety of analytical techniques are described with regard to their use in quantitative determination and identification. Teaching will focus on the design and use of apparatus as well as potential sources of error. There will also be focus on quality assurance and validation of analytical methods, including the significance of linearity, accuracy, precision, sensitivity, determination limits, blind values, selectivity and interference.

The students take turns giving presentations on the performed practical exercises and the finding of the exercises are discussed and related to the theory of the applied instrumentation. In the practical exercises, students work with fixed demonstrations of separation and detection methods. They simultaneously work on a project where they plan and try out a number of these techniques on a given drug. The analytical techniques are UV/VIS spectrophotometry, liquid chromatography (HPLC), gas chromatography (GC), mass spectrometry (MS) and atomic absorption spectrometry (AAS). The students carry out experiments in groups and submit a joint report. Reports are assessed by the teacher and discussed on return.

Education

MSc Programme in Pharmaceutical Sciences (English programme): Line II ('Drug Development' track) - compulsory

MSc Programme in Pharmaceutical Sciences (English programme): Line I & II - elective

MSc Programme in Medicinal Chemistry - elective

Learning outcome

To enable students to develop and use analytical chemical methods in connection with development of drug substances, as well as identification and quality assessment of drugs and excipients.

At the end of the course, students should be able to:

Knowledge

  • explain the principle of the techniques, their areas of application and potential sources of error
  • understand the methodological terminology required for reading literature and writing reports
  • assess the reliability of analytical data
  • report experiments briefly, clearly and unambiguously.

 

Skills

  • perform quantitative calculations based on various calibration methods in connection with the analytical chemical methods applied
  • perform validation of an analytical method.

 

Competences

  • Have adequate theoretical and practical knowledge of a wide variety of analytical chemical techniques to independently plan and perform quantitative determinations using relevant analytical methods

•Exercises/project: 16 four-hour sessions plus report writing
•Discussion classes: 8 two-hour sessions

  • D.C. Harris: Quantitative Chemical Analysis, 9th edition, W.H. Freeman and Company, New York, 2016.
  • Compendium in Pharmaceutical Analytical Chemistry, latest edition, Department of Pharmacy, University of Copenhagen. Is available on the course home page via Absalon.

Students should have accumulated at least 15 ECTS credits in chemical subjects, of which 10 ETCS credits should be in the field of organic chemistry.

Registration for the exam is contingent on approval of all reports from the laboratory exercises.

Written
Oral
Collective
ECTS
7,5 ECTS
Type of assessment
Written examination, 2 hours under invigilation
Multiple choice exam.
Aid
Written aids allowed

There is access to the following at the exam on Peter Bangs Vej:

  • Office (Word, Excel, Onenote and Powerpoint)
  • IO2 – the digital pen
  • Panoramic Viewer
  • Paint
  • Calculator – Windows' own
  • R – Statistical programme
  • ITX MC – multiple choice programme
  • Adobe reader
  • USB access – for usb stick with notes etc.

 

Use of books, notes, lecturs slides etc. is permitted, also if the materials are on digital form on a USB flash drive.

Marking scale
7-point grading scale
Censorship form
No external censorship
Criteria for exam assessment

To achieve the grade 12 the student must be able to:

Knowledge

  • explain the principle of the techniques, their areas of application and potential sources of error
  • understand the methodological terminology required for reading literature and writing reports
  • assess the reliability of analytical data
  • report experiments briefly, clearly and unambiguously.

 

Skills

  • perform quantitative calculations based on various calibration methods in connection with the analytical chemical methods applied
  • describe the analytical methods applied in selected reports and demonstrate ability to perform quantitative determinations based on analytical data.

 

Competences

  • Have adequate theoretical and practical knowledge of a wide variety of analytical chemical techniques to independently plan and perform quantitative determinations using relevant analytical methods

Single subject courses (day)

  • Category
  • Hours
  • Preparation
  • 50
  • Practical exercises
  • 64
  • Project work
  • 92
  • English
  • 206