Kursussøgning, efter- og videreuddannelse – Københavns Universitet

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Kursussøgning, efter- og videreuddannelse

Cellular Neuroscience

Practical information
Study year 2016/2017
Time
Block 1 And Block 4
Programme level Bachelor
ECTS 7,5 ECTS
Course responsible
  • Jean-Francois Marie Perrier (7-746976766d69764477797268326f7932686f)
  • Department of Neuroscience and Pharmacology
Course number: SMOB14001U

Course content

The goal of the course is to give the students an overview of methods used to study functions of the central nervous system. We provide an insight in signaling mechanisms in neurons and networks of neurons by describing how the molecular mechanisms of electrical and chemical signalling are adapted to serve synaptic transmission, synaptic integration and nerve impulse generation. The Course illustrates how experiments led to textbook knowledge and provide insight in experimental procedures, techniques and preparations.
The course includes theoretical and practical elements. The theory focuses on cellular and molecular properties of neurons and their implications in physiological functions.
In addition to basic subjects, the course highlights a) The role of the non-linear postsynaptic properties provided by voltage sensitive ion channels in dendrites.
b) Modulation of these properties by G-protein coupled receptors.
c) Functional specialization of cell types in particular brain regions and
d) Signaling networks in particular brain regions.
The Practical part includes demonstrations of preparations of nerve tissues in vitro, recording electrical activity from neurons with patch clamp techniques in slices preparations. Each student gets the opportunity to record from living neurons and to characterize some of the transmembrane currents responsible for firing properties by means of electrophysiological and pharmacological tools.

Learning outcome

Knowledge

After completing the course the student is expected to be able to 

  • describe synaptic transmission, long term potentiation
  • explain the mechanims responsible for membrane potential, nerve impulse propagation.
  • understand electrophysiological techniques such as extracellular recording, patch clamp, voltage clamp, current clamp.
  • understand the concepts of membrane resistance, conductance, ion channel density.

 

Skill

After completing the course the student is expected to be able to 

  • determine which recording techniques should be used to investigate a scientific problem in neuroscience.

 

Competence

After completing the course the student is expected to be able to 

  • read and understand scientific articles in neuroscience
  • make a didactic oral presentation of scientific articles

 

Recommended prerequisites

Open to students in Molecular Biomedicine, Biochemistry, Nanotechnology, Pharmacy, the physical sciences with specialization in Biophysics, Veterinary school, Biology and Foreign European Universities that have passed relevant first and second year courses.

Education

BSc Programme in Biochemistry
BSc Programme in Molecular Biomedicine

Studyboard

Study Board of Biomolecular Sciences and Technology

Teacher

Jean-Francois Perrier
Jørn Hounsgaard
Jakob Baslev Sørensen

Duration

1 block

Schedulegroup

C
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Teaching and learning methods

Classroom teaching, group discussions and laboratory exercises

Capacity

32 participants

Language

English

Literature

Cellular and Molecular Neurophysiology, 4th Edition

Author : C  Hammond   

Release Date:02 Jan 2015

Imprint:Academic Press

eBook ISBN :9780123973221

Print Book ISBN :9780123970329

Pages:444

Workload

Category Hours
Lectures 15
Class Instruction 15
Practical exercises 12
Preparation 163,5
Exam 0,5
English 206,0

Exam

Type of assessment

Oral examination
A 12 minutes oral presentation of one article subject within the course combined with a discussion about the article and the content of the module.

Aid

All aids allowed

Marking scale

7-point grading scale

Criteria for exam assessment

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Censorship form

No external censorship
More than one internal examiner

Re-exam

Same form as for the first exam (the practical lab course must be approved).

Mere information om kurset
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