Kursussøgning, efter- og videreuddannelse – Københavns Universitet

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Kursussøgning, efter- og videreuddannelse

Principles of Pharmacology

Practical information
Study year 2016/2017
Time
Block 1
Programme level Full Degree Master
Full Degree Master choice
Part Time Master
ECTS 7,5 ECTS
Course responsible
  • Anders Skov Kristensen (3-63756d4275777066306d7730666d)
  • Department of Drug Design and Pharmacology
Course number: SLVKB0351U

Course content

The course deals with the following topics:

  • Neurotransmitter systems and neuropharmacology
  • Fundamental nerve/muscle/cell physiology with special focus on membrane physiology and synaptic mechanisms
  • Receptor pharmacology including receptor classifications, agonists, antagonists, development of tolerance, and analysis of receptor-ligand interactions

  • Pharmacodynamics: Dose-response relationships, dose/time relationships, use of biological systems to estimate activities of drugs, statistical analysis of biological data

  • Pharmacokinetics: General kinetics, absorption, distribution, elimination, metabolism, excretion and drug interactions

  • Drug development methods: Animal models, preclinical development and concepts of toxicology

Learning outcome

At the end of the course, students are expected to be able to:

 

Knowledge

  • Students will obtain a fundamental understanding and knowledge of the basic concepts of pharmacology and the related human physiology.

 

Skills

 

  • calculate pharmacokinetic parameters of a drug from plasma concentrations time-course
  • understand the different mechanisms of action of antagonists
  • interpret antagonist pharmacological data to determine mechanism of action
  • propose experiments to distinguish antagonist mechanism of action
  • have a basic understanding of neurotransmission and neurotransmitter systems in the CNS
  • have an understanding of drug toxicity and adverse effects
  • have an understanding of clinical trials and drug monitoring

 

Competences

 

  • Understand concepts used in physiology and basic pharmacology.
  • Calculate, estimate and discuss physiological and pharmacological parameters obtained from experimental and clinical data (pharmacodynamic and pharmacokinetic data).
  • Discuss and explain pharmacology-related procedures and methods used in preclinical drug development.
  • Effectively communicate pharmacological and drug information to others within the fields of pharmaceutical sciences and health sciences

Recommended prerequisites

Course teaching is based on the assumption that students have passed exams in chemistry subjects corresponding to at least 15 ECTS credits, of which 10 ECTS credits should be in organic chemistry and biology, and 15 ECTS credits in biochemistry and/or molecular biology and/or microbiology.

Mandatory prerequisites

None.

Remarks

Except for students enrolled at the MPS this course is not available to those who have previously passed an introductory pharmacology lecture course, such as: almen farmakologi (SFABB0251U) or grundlæggende farmakologi (SFABB1011U).

Education

MSc in Pharmaceutical Sciences - compulsory
 

Studyboard

Study Board of Pharmaceutical Sciences

Teacher

Annouced at course start.

Duration

1 block

Schedulegroup

A
---- SKEMA LINK ----

Teaching and learning methods

• 31 lectures
• 20 hr of tutorial lessons
• 4 hours of laboratory work
• 1 project presentation (group work)

Capacity

70 students
Reserved for students at the MSc programme in Pharmaceutical Sciences.

Language

English

Literature

  • Silverthorn: Human Physiology, 6th edition, Pearson International, 2014.
  • Rang, H.P., Dale, M.M., Ritter, J.M. & Flower, R. J.: Pharmacology, 8th edition, Churchill Livingstone, 2015.
  • Rowland, M. & Tozer, T.N.: Clinical Pharmacokinetics and Pharmacodynamics. Concepts and Applications. 4th edition, Lippincott, Williams & Wilkins, 2011.
  • Meldgaard Lund, T. and Sheykhzade M., FARMA, KU: Pharmacokinetic and -dynamic Equations and Preconditions (on the homepage).
  • Sheykhzade and Pickering: Pharmacodynamic theory notes, 9th ed, 2013 (on the homepage).

Workload

Category Hours
Lectures 31
Preparation 62
Project work 20
Class Instruction 40
Exercises 4
Exam Preparation 50
English 207

Exam (SLVKB0351E - written examination)

Type of assessment

Written examination, 3 hours under invigilation
Exam assessment is based on a written, closed-book exam with 4 different topics and each topic with 4 subparts. The individual weighting of each question will be clearly stated on the exam paper.

Overall impression forms part of the exam assessment and may cause the score to be adjusted by up to 10%. The adjustment is based on the demonstration of an overall understanding of basic pharmacological principles and topics and the absence of major weaknesses.

Aid

Without aids

Refer to the IT exams homepage link where the standard programs and IT tools available for the students’ disposal during IT exams under The Faculty of Health and Medical Sciences are listed.

Students will at this exam also have access to MathType.

Marking scale

7-point grading scale

Criteria for exam assessment

To achieve the grade 12 the student must be able to:


 Knowledge

  • understand the relevant terms, principles and methods used in physiology and pharmacology.
  • Refere fundamental understanding and knowledge of the basic concepts of pharmacology and the related human physiology.
  • have a basic understanding of neurotransmission and neurotransmitter systems in the CNS
  • have an understanding of drug toxicity and adverse effects
  • have an understanding of clinical trials and drug monitoring
  • Understand concepts used in physiology and basic pharmacology.

 

Skills

 

  • calculate pharmacokinetic parameters of a drug from plasma concentrations time-course
  • understand the different mechanisms of action of antagonists
  • interpret antagonist pharmacological data to determine mechanism of action
  • propose experiments to distinguish antagonist mechanism of action

 

Competences

 

  • Calculate, estimate and discuss physiological and pharmacological parameters obtained from experimental and clinical data (pharmacodynamic and pharmacokinetic data).
  • Discuss and explain pharmacology-related procedures and methods used in preclinical drug development.
  • Effectively communicate pharmacological and drug information to others within the fields of pharmaceutical sciences and health sciences

Censorship form

No external censorship
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