Kursussøgning, efter- og videreuddannelse – Københavns Universitet

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Kursussøgning, efter- og videreuddannelse

Pharmacokinetics and Pharmacodynamics

Practical information
Study year 2016/2017
Time
Block 2
Programme level Full Degree Master
Full Degree Master choice
Part Time Master
ECTS 7,5 ECTS
Course responsible
  • Trine Meldgaard Lund (10-7c7a71766d36747d766c487b7d766c36737d366c73)
  • Department of Drug Design and Pharmacology
Course number: SFKKB9001U

Course content

Lectures covering PK-PD relationships, as well as distribution, metabolite kinetics, effect at receptor and ionchannel level, effect measurement, dose-effect relationships, population methods, simulation of PK-PD relationships and variability in PK-PD response and dosing to different patient populations.

Computer sessions for pharmacokinetic pharmacodynamic modeling using the program Phoenix WinNonlin and Microsoft Excel.

Learning outcome

At the end of the course, students are expected to be able to:

Knowledge

  • Demonstrate knowledge of pharmacokinetic (PK) and pharmacodynamic (PD) in the individual as well as the population
  • Understand how to calculate PK and PD parameters and use them in a quantitative description of the interaction between a drug and the body over time.
  • Obtain knowledge on variability in patient populations

 

Skills

  • Obtain insight and hands-on experience with pharmacokinetic and –dynamic data analysis, based on different examples of plasma concentration-time course linked to therapeutic response.
  • obtain experience with the modelling software Phoenix WinNonlin and Microsoft Excel for data analysis.
  • Apply knowledge on variability in patient populations to a PKPD analysis that can be used to describe variability in response in different patient segments and in drug research and illustrate development within the pharmaceutical industry.

 

Competences

  • Design dosing strategies in different clinical situations based on their knowledge about PKPD (e.g. taking variations such as demographics, organfunction, pharmacogenetics, comobidity and interactions into account).
  • Design experiments for the drug research and development based on their knowledge about PKPD

 

Recommended prerequisites

Participation and exam in either Basic Pharmacology or Principles of Pharmacology or similar, as the student should be familiar with the basic pharmacokinetic parameters and calculations, concepts determining variability in order to suggest individual dosing as well as knowledge and competence for reasoning on PKPD information

Mandatory prerequisites

None.

Sign up

Open for Danish and international guest students. For application details look here: http://sund.ku.dk/uddannelse/andre-uddannelsestilbud/meritstuderende/.

Education

MSc in Pharmaceutical Sciences - elective, MSc in Medicinal Chemistry - elective, Cand.Scient.Pharm. - elective, Cand.Pharm. - elective

Studyboard

Study Board of Pharmaceutical Sciences

Duration

1 block

Schedulegroup

A
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Teaching and learning methods

Lectures: 24 lectures
Tutorials/computer sessions: 15 hours

Capacity

30 students

Language

English

Literature

  • M. Rowland and T. Tozer, Clinical Pharmacokinetics and Pharmacodynamics, ed. 4, 2011
  • Notes and lecture hand-outs available on the course homepage

Workload

Category Hours
Lectures 24
Exam 85
Preparation 78
Theory exercises 15
English 202

Exam (SFKKB9001E - written examination)

Type of assessment

Written examination, 3 hours under invigilation
Permitted aids: Textbooks, all written course material from the homepage.
Examiners: Course teachers

Aid

All written aids allowed.

Refer to the IT exams homepage link where the standard programs and IT tools available for the students’ disposal during IT exams under The Faculty of Health and Medical Sciences are listed.

During the exam, students will have access to MathType and the possibility to use a USB stick (for notes etc.)

Marking scale

7-point grading scale

Criteria for exam assessment

To achieve the grade 12 the student must be able to:

Knowledge

  • Demonstrate knowledge of pharmacokinetic (PK) and pharmacodynamic (PD) in the individual as well as the population
  • Understand how to calculate PK and PD parameters and use them in a quantitative description of the interaction between a drug and the body over time.
  • Obtain knowledge on variability in patient populations

 

Skills

  • Obtain insight and hands-on experience with pharmacokinetic and –dynamic data analysis, based on different examples of plasma concentration-time course linked to therapeutic response.
  • obtain experience with the modelling software Phoenix WinNonlin and Microsoft Excel for data analysis.
  • Apply knowledge on variability in patient populations to a PKPD analysis that can be used to describe variability in response in different patient segments and in drug research and illustrate development within the pharmaceutical industry.

 

Competences

  • Design dosing strategies in different clinical situations based on their knowledge about PKPD (e.g. taking variations such as demographics, organfunction, pharmacogenetics, comobidity and interactions into account).
  • Design experiments for the drug research and development based on their knowledge about PKPD

 

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