Kursussøgning, efter- og videreuddannelse – Københavns Universitet

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Kursussøgning, efter- og videreuddannelse

Experimental Analytical Chemistry: Method Development and Quality Assurance

Practical information
Study year 2016/2017
Block 2
Programme level Full Degree Master
Course responsibles
  • Jan H. Christensen (3-7a737850807c757e3e7b853e747b)
  • Peter Waaben Thulstrup (3-808784507378757d3e7b853e747b)
  • Department of Plant and Environmental Sciences
  • Department of Food Science
  • Department of Chemistry
Course number: NPLK16003U

Course content

The course topics include: An introduction to problem solving in analytical chemistry (method development and quality assurance). Guidelines for method development in analytical chemistry will be presented and discussed with special focus on chromatographic, spectroscopic and mass spectrometric methods. Experimental design for optimizing analytical methods. Guidelines for method validation and quality control at different stages of the analytical process will be presented, discussed and tested (e.g., precision, robustness, accuracy, limit of detection, limit of quantification). The main focus will be on an experimental project involving method development, validation, quality assurance (QA), quality control (QC), Good Laboratory Practice (GLP), data processing, data evaluation and documentation and scientific writing.

Learning outcome

The course objective is to introduce the participants to the methods and techniques used to solve problems in analytical chemistry: method development, quality assurance, quality control as well as GLP and documentation. This background is useful for all kinds of experimental analytical work including applications within plant biology, environmental- food- and soil chemistry.

After completing the course the student should be able to:

Describe the theory and practice of method development, validation, quality assurance, GLP and documentation in analytical chemistry.
Refer to the statistical theory behind QA for quantitative chemical analysis

Independently setup experiments, develop, validate and make documentation for an analytical method.
Set up and apply a quality control system for an entire analytical method.

Develop, validate and apply analytical methods in different field of research.
Evaluate and discuss analytical chemical quality data from the literature.
Do problem solving in analytical chemistry: method development and QA/QC measures.

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MSc in Chemistry


Study Board of Physics, Chemistry and Nanoscience

Course type

Single subject courses (day)


1 block


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Teaching and learning methods

Lectures: The lectures will present the general theory for problem oriented analytical chemistry, experimental design, method development, quality assurance, method validation and scientific writing.

Theoretical and minor laboratory exercises: these will train the students to carry out QA/QC and to perform optimize analytical methods based on theory. Theoretical exercises and minor laboratory exercises are performed in groups of 2 to 4 students.

Laboratory project: The Laboratory projects represent the heart of the course. Here, the participants train aspects of method development, quality assurance and control as well as GLP and documentation for analytical work. The laboratory exercise comprises one project performed in groups of 2-4 students, the subject of which could be an experimental study related to the participants own master projects.






Details regarding literature will be available on Absalon.

Course teachers: Compendium for laboratory exercises and handouts





Category Hours
Lectures 18
Theory exercises 14
Practical exercises 56
Excursions 4
Exam 1
Preparation 109
Colloquia 4
English 206


Type of assessment

Oral defence, 30 min.
Oral examination based on project report and theory.
30 min oral examination per student divided into two parts: 1) examination in the written report, and 2) examination in the general method development and quality assurance.
Weight: The project examination 2/3, theoretical question 1/3

Marking scale

7-point grading scale

Criteria for exam assessment

According to the learning outcome

Censorship form

External censorship


Oral examination based on project report (handed in monday in the week before the week of exam) and theory.
30 min oral examination per student divided into two parts: 1) examination in the written report, and 2) examination in the general method development and quality assurance.
Weight: The project examination 2/3, theoretical question 1/3

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