Kursussøgning, efter- og videreuddannelse – Københavns Universitet

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Kursussøgning, efter- og videreuddannelse

Reactions and Synthesis in Medicinal Chemistry (KemiMed)

Practical information
Study year 2016/2017
Time
Block 1 And Block 2
Programme level Full Degree Master
ECTS 15 ECTS
Course responsible
  • Jørn Bolstad Christensen (3-70686946696e6b7334717b346a71)
  • Department of Chemistry
Course number: NKEK13007U

Course content

The topics are: Transition-metal catalyzed reactions including cross-coupling reactions; Stereospecific aldol-additions; Chiral auxilaries; Pericylic reactions including click-chemistry; Rearrangements; Fragmentations; Radical reactions including carbenes; Microorganisms and enzymes in synthesis; Methods for the resolution of racemic mixtures: Classical resolution, enzymatic resolution, spontaneous resolution and methods for determination of optical purity; Microfluidics in synthesis; Solid-phase supported reagents for synthesis; Case stories from the medicinal industry: What is an invention? Scalability problems.

Learning outcome

 

Competencies
Be able to analyze a complex synthetic problem and plan a feasible synthesis.
Be able to analyze scientific papers and patents dealing with synthetic problems and be able to spot inconsistent claims.

Skills
Apply the aquired knowledge on organic synthesis on a given target molecule. Be able to translate known methodologies to new problems.

K
nowledge
Have an in depth knowledge of modern synthetic organic synthesis according to the content of the course.

 

Recommended prerequisites

It is expected that the students are familiar with the content of the courses KemiU1, KemiU2, KemiO, KemiBin, AnvSpek, FysKem1, FysKem2, KemiVO, OrgSyn (eller VidOrgSyn).

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Education

MSc Programme in Chemistry
MSc Programme in Medicinal Chemistry

Studyboard

Study Board of Physics, Chemistry and Nanoscience

Course type

Single subject courses (day)

Duration

2 blocks

Schedulegroup

A
---- SKEMA LINK ----

Teaching and learning methods

Lectures, problem solving in class and written take-home assignments

Capacity

No admission restriction

Language

English

Literature

Will be announced on Absalon

Workload

Category Hours
Lectures 26
Theory exercises 52
Preparation 333
Exam 1
English 412

Exam

Type of assessment

Oral examination, 30 min
The exam is an oral examination based on one of the take-home assignments chosen randomly (by lot). There is no preparation time

Marking scale

7-point grading scale

Criteria for exam assessment

See Learning Outcome

 

Censorship form

External censorship

Re-exam

The re-examination is also an oral examination based on one of the take-home assignments chosen randomly (by lot).

All missing take home assignments must be submitted no later than two weeks prior to reexam.

Mere information om kurset
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